Qwen 2.5 72B Instruct on NVIDIA GeForce RTX 3080 10GB
NVIDIA GeForce RTX 3080 10GB cannot run Qwen 2.5 72B Instruct at any quantization level. The 10 GB of VRAM is insufficient.
Model Size
72.7B
Device VRAM
10 GB
Bandwidth
760 GB/s
Quantizations Tested
1
Performance by Quantization
Each row shows Qwen 2.5 72B Instruct performance at a different quality level on NVIDIA GeForce RTX 3080 10GB.
| Quantization | Speed | TTFT | Fits in VRAM | Rating | Confidence |
|---|---|---|---|---|---|
| Q2_K | — | — | ✗ Offload | Not Viable | estimated |
Notes
Q2_K
72B doesn't fit in 10GB.
About Qwen 2.5 72B Instruct
Qwen 2.5 72B Instruct (72.7B) is a chat, coding, ai coding, reasoning, multi-purpose model. Top-tier 72B model, competitive with Llama 3.1 70B. Excellent at coding and structured output. Requires 48GB+ VRAM for usable quantizations.
View all Qwen 2.5 72B Instruct hardware options →About NVIDIA GeForce RTX 3080 10GB
NVIDIA GeForce RTX 3080 10GB has 10 GB at 760 GB/s. Street price: $399.
See all models NVIDIA GeForce RTX 3080 10GB can run →Source: Performance estimates based on model size and device bandwidth (2026-03-15)
Data last updated: 2026-03-01